Does Testosterone Replacement Therapy cause Prostate Cancer?

Based on findings from one of the most comprehensive trials on Testosterone Replacement Therapy (TRT), the answer is No!

If you’ve followed our recent posts on TRT, you’ll know that the TRAVERSE study evaluated TRT’s long-term safety and efficacy in men aged 45-80 with low testosterone levels. If you haven’t checked out our previous posts yet and have doubts about the safety of TRT (under the guidance of a qualified medical professional), we would definitely encourage you to give them a read. We’ve also provided a link to the full TRAVERSE study at the bottom of each post, just in case you’d like to check out the findings on your own.

Findings from the TRAVERSE study provide reassuring insights on prostate health and the safety of TRT for men with hypogonadism. Among its key findings, the study revealed that TRT does not significantly increase the risk of prostate cancer. Over the course of the trial, the incidence of prostate cancer was 0.9% in the TRT group compared to 0.8% in the placebo group – an insignificant difference. Additionally, no notable changes in prostate-specific antigen (PSA) levels or other prostate-related issues were observed between the groups.

These results are pivotal in addressing concerns about TRT and prostate health. They suggest that, when administered under medical supervision, TRT is a safe option for men seeking to alleviate symptoms of low testosterone, such as fatigue, reduced libido, and mood changes. For men considering TRT, the TRAVERSE study offers evidence-based reassurance that prostate health can be maintained while benefiting from the therapy. 

The Bottom Line

Key risk factors for prostate cancer include advancing age, a family history of the disease, African ancestry, and inherited genetic mutations. While testosterone replacement therapy (TRT) is unlikely to elevate your risk, regular screening for these risk factors is crucial. Regular monitoring, including PSA levels and prostate health assessments, will ensure early detection if any issues arise.

Interested in improving your well-being through Testosterone Replacement Therapy while prioritizing prostate health? Connect with a board-certified provider at Limitless Men’s Health and TRT today to explore your options!

Link to the full TRAVERSE study: Cardiovascular Safety of Testosterone-Replacement Therapy